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Tissue penetrability as a function of nanoparticle delivery | 95119
International Research Journals

Tissue penetrability as a function of nanoparticle delivery mode

Abstract

Roxana Florentina Sufaru*, AnaMarina Radulescu, Ruxandra Vatavu, Anca Sava, Liviu Ciprian Gavril and Cosmin Popa

The study conducted at CEMEX Iasi was carried out on 2 groups of Wistar rats to which nanoparticles loaded with contrast agent were administered intraperitoneally and nasogastrically. The two modes of administration offered a comparison in terms of tissue penetrability. Histological samples were obtained from organ sections (heart, liver, kidney, gingiva, testis) and analysed using the NIKON Y-FL ECLIPSE E600 immunofluorescence microscope at the "Professor Doctor Nicolae Oblu" Emergency Clinical Hospital in Iasi. In terms of immunofluorescence our study showed a difference only in the case of sections taken from the gingiva.

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