Short Communication
N-linked Glycosylation and Its Potential within Different Rat Strain´S Pharmacology Basic Research
Author(s): Zuzana Brnoliakova*
Statement of the Problem: Glycosylation is one of the
most common posttranslational modifications of proteins.
Altered glycosylation is present in many
pathophysiological conditions. Glycomic studies on rat
serum have revealed variations in the N-glycans of
glycoproteins correlated with disease progress, which is
consistent with the findings in human serum. The main
goal of our study was to describe the glycoprofiles of
different rat strains fed 5 weeks standard diet and to
evaluate their differences according to the N-glycan type.
Methodology & Theoretical Orientation: For our
observation we used Wistar rats (W), the general
multipurpose model strain. Then spontaneously
hypertensive rats (SHR) were used, developed as animal
models for human essential (idiopathic or primary)
hypertensions. Finally, hereditary hypertriglyceridemic
rats (hHTG) were also included, regarded a.. View More»