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Uses of Micro Sample and Micro Extraction for Evaluation of Drug Abuse
Author(s): Siddharth Dutta*
96-well liquid solution micro-extraction and ultra-high-performance liquid chromatography tandem mass
spectrometry analysis were used to evaluate a novel approach that combined micro-sampling of whole blood
containing drugs of abuse. The most promising configuration was confirmed after being tested with various donor
solutions, supported liquid membranes, and acceptor solutions. Opioids, cocaine, amphetamines, benzodiazepines,
and z-hypnotics, among others, were included in the approach. 13 of the compounds had extraction recoveries
greater than 70%, while the final four compounds had recoveries between 10 and 58%. The current method did
not extract THC. Except for morphine, a linear calibration model was discovered for all drugs. For all compounds,
except for morphine and zopiclone, which had a CV of 25% at LOQ, limits of quantitation were between 1 and
5 ng/mL, and inter-day pr.. View More»
DOI:
10.14303/2141-5153.2023.56