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Causative Agent Resistant To Wear Cyst Fluid Protein Purification Investigation By Shotgun LC-MS/MS Taenia Solium Cysts From Pigs' Skeletal Muscle And Central Nervous System Were Subjected To Quantitative Multiplexed Proteomics.
Author(s): Shuchang Yichen*
The larval stage (cysts) of the tapeworm Taenia solium, which causes human and porcine cysticercosis, can infest a variety of tissues, including the skeletal muscles and the central nervous system (CNS) (SM). The proteome alterations brought on by the cyst's tissue localisation in the host tissues have received less attention. The ability to assess global proteome alterations in response to various situations is strength of quantitative multiplexed proteomics. Here, we used a TMT-multiplexed method to identify and quantify more than 4,200 proteins, 891 of which were host proteins, in cysts isolated from the SM and CNS of pigs. This is the most comprehensive host and parasite protein mixing associated with tapeworm infections that have been documented to our knowledge. Skeletal muscle cysts were enriched in a number of cysticercosis antigens, including GP50, paramyosin, and a calci.. View More»
DOI:
10.14303/2141-5153.2022.25