Mini Review
Pediatric Brain Tumors and Models of Pioneering
Author(s): Shilu Singh*
Brain and other central nervous system tumours are the second most frequent kinds of cancer among children
and adolescents in the United States, after only leukaemias in incidence. Brain cancer continues to be the primary
cause of mortality in children despite major advancements in detection and treatment options. It is clear that there
is a need to enhance these patients' survival rates and streamline the therapy approaches. Preclinical models are
essential for that goal. Pediatric brain tumour research employs a variety of models, including genetically modified
mouse models, patient-derived xenografts and cell lines, and more recent models that make use of cutting-edge
technologies like genome editing and organoids. Researchers from the Children's Brain Tumor Network and
others have conducted significant research that has discovered multiomic landscapes. Of diverse children's br.. View More»
DOI:
10.14303/irjbcs.2023.23