Mini Review
Protein 3D Structure, Functional Characterization And Sequence Information For Proteinâ??protein Interaction Prediction
Author(s): Shahbaz Ali*
The function of a protein limits its evolutionary path through sequence space. Sequence homolog collections document the results of millions of evolutionary experiments in which the protein changes in accordance with these limitations. It is extremely difficult to decipher the evolutionary history contained in these sequences and use it for engineering and prediction applications. Due to the development of low-cost high-throughput genome sequencing, the potential value of resolving this problem has increased (Knop D et al., 2015). It is difficult to separate genuine co-evolution connections from the chaotic collection of apparent correlations. We tackle this problem by inferring residue pair couplings using a maximum entropy model of the protein sequence, restricted by the statistics of the multiple sequence alignment. Unexpectedly, we discover that the strength of these inferred coup.. View More»
DOI:
10.14303/2250-9941.2022.35