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Planning, Scheduling and Period of Drug Vulnerability Impact Pharmacodynamics Result throughout Morphogenesis
Author(s): Saripal Vinuchi*
When nutrients and drugs share the same absorption and disposition mechanisms, significant interactions between the two substances can occur. Because these processes undergo ontogenesis throughout the postnatal period, the outcomes of drug-nutrient interactions may change with postnatal age during development. Cefepime-carnitine, a significant drug-nutrient interaction, was found to be dependent on drug exposure timing and duration in relation to postnatal age in our study. Cefepime (5 mg/kg) was given to rat pups twice daily by subcutaneous injection on various dosing schedules. In the postnatal day 1-4, 1-8, and 8-11 groups, cefepime caused severe degenerative changes in the ventricular myocardium and significantly reduced serum and heart L-carnitine levels. Additionally, the ontogeny of a number of important L-carnitine homeostasis pathways was altered by cefepime. The time and dur.. View More»
DOI:
10.14303/2251-0176.2023.62