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Effects of DNA Ordering, Cleavage, and Coordination in Non-Cancer Cells
Author(s): Sana Yasmeen*
A series of arylazo sulfones known to cleave NÀS bonds upon exposure to light have been synthesized and their
activities studied in the dark and upon irradiation to DNA. Interactions with calf thymus DNA were studied and
the observed significant affinities (most likely due to DNA intercalation) were analyzed by in silico molecular
docking calculations, suggesting that polar contacts were predominantly through sulfonyl moieties. Incubation
with plasmid pBluescript KS II showed DNA cleavage, which was examined over time and concentration.
Exposure to UV-A greatly ameliorated DNA damage for most compounds, but the effect was slightly reduced
under visible light. As for in vitro experiments, we found that cell death of most compounds was slightly enhanced
by irradiation. Photodestructive effect under UV-A irradiation (IC50-13 ?M), (IC50-100 ?M). These compounds
were irradiated in the.. View More»
DOI:
10.14303/2141-5153.2023.33