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Understanding Pharmacokinetics: The Journey of Drugs in the Body
Author(s): Ramesh Majhi*
Pharmacokinetics is a vital discipline within pharmacology that elucidates the intricate processes governing the fate of drugs in the human body. This article delves into the core concepts of pharmacokinetics, encapsulating the journey of drugs through the body as described by the acronym ADME: Absorption, Distribution, Metabolism, and Excretion. Absorption marks the commencement of a drug's voyage as it enters the bloodstream through various routes, influenced by diverse factors such as administration method and chemical properties. Distribution entails the transportation of the drug to different tissues and organs, guided by solubility, binding, and tissue permeability. Metabolism, a pivotal aspect, involves enzymatic transformation of drugs, rendering them less potent and more amenable to elimination. Excretion, the final phase, expels drugs and metabolites through urine and fe.. View More»