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A Rapidly Developing Biotechnology Field For Cancer Therapy And Other Bioactivities: Medicinal Mushrooms When Androgen And Glucocorticoid Receptors Are Targeted Differently; Prostate Cancer Cells Experience ER Stress And Apoptosis.
Author(s): Portia Collier*
When it comes to prostate cancer, androgen (AR) and glucocorticoid (GR) receptor signalling play opposing
roles: in the prostate, AR functions as an oncogene and GR as a tumour suppressor. Recently, we discovered
that the non-steroidal phytochemical compound A (CpdA) is an anti-inflammatory anti-androgen that modulates
AR/GR. CpdA suppresses GR transrepression while suppressing AR and preventing GR transactivation.
Degradation by proteasomes regulates GR and AR. We discovered that prolonged treatment with the proteasome
inhibitor Bortezomib (BZ) resulted in the accumulation of GR and the degradation of AR in prostate cancer
(PCa) cells LNCaP, LNCaP-GR, DU145, and PC3. BZ improved CpdA's capacity to suppress AR and increase
GR transrepression. Additionally, we discovered that CpdA+BZ differently regulated GR/AR to inhibit PCa
cell growth and survival while simul.. View More»
DOI:
10.14303/2141-5153.2022.24