Annual Meeting Abstract
Maintaining Vascular Architecture: A Key Challenge In Creating A Bioartificial Kidney
Author(s): Peter R Corridon*
A fully functional bioartificial kidney would be an epic medical achievement that can address the growing need for renal transplantation. Various research efforts across the globe are focused on developing such a device. Decellularization technologies seem to be a promising approach. This technique removes the native cellular components from discarded human and intact pig organs and leaves behind and extracellular matrix scaffold of the original organ. These scaffolds can then be used as templates to generate bioartificial organs. Yet, the complexity of the renal structure and the present limited understanding of how best researchers can leverage decellularization technologies to support longterm transplantation emphasize how far away we are from achieving this goal. Further work is therefore needed to define ways to maintain vascular integrity post-transplantation. As a result, the o.. View More»