Short Communication
Characterization of novel interactions with plasma membrane NEU1 reveals new biological functions for the Elastin Receptor Complex in vascular diseases
Author(s): P Maurice*
Remodeling of elastin during pathophysiological vascular
aging leads to the production of elastin-derived peptides
(EDP), also known as elastokines. These peptides trigger
biological effects through the elastin receptor complex
(ERC). Data from the last decade have brought significant
insights on the critical role played by its catalytic subunit,
Neuraminidase-1 (NEU1), in the biological effects
mediated by EDP in vascular and metabolic diseases. We
recently developed a proteomic approach dedicated to the
purification and identification of membrane NEU1-
associated protein complexes in human macrophages and
identified several promising candidates (Kawecki et al,
CMLS. 2019). Here, we validated and characterized two
novel interactions with NEU1 in human monocytes and
endothelial cells involving the ?2 integrin and ICAM-1,
respectively. We show that binding of EDP to the ERC.. View More»