+44 330 818 7254 Short Communication
Clinical Microbiology 2015: Mechanisms of anti-retroviral drug-induced changes in amyloid precursor protein processing: Implications for HAND- Kelly L Jordan-Sciutto- University of Pennsylvania
Author(s): Kelly L Jordan
HIV-associated neuro-cognitive disorders (HAND) persist in 30-50% of HIV positive patients despite viral control by antiretroviral therapy (ART). Several studies indicate a potential role for anti-retrovirals in the persistence of HAND and evolution from a sub-acute, sub-cortical dementia to a cortical, neurodegenerative disease. Based on their ability to induce ER stress in a wide variety of cell types, we hypothesized that HIV protease inhibitors (PI) induce ER stress in the CNS, resulting in chronic dysregulation of the unfolded protein response (UPR) which in turn alters amyloid precursor protein (APP) processing by inducing the.. View More»