Mini Review
Tellurium Modified Nucleosides, Nucleotides, and Nucleic Acids
Author(s): Catherine James*
Here, we present the first synthesis of the Tephosphoramidite and 5-phenyl-telluride-thymidine derivatives. Additionally, we provide here investigations on DNA oligonucleotides that have the nucleobase (thymine) derivatized with 5-phenyl-telluride activity, including their synthesis, structures, and STM current imaging (5- Te). Te-DNA duplex possesses thermo-stability comparable to the corresponding native duplex, while 5-Te-DNA is stable. The 5-Te-DNA duplex structure is nearly equivalent to the native one, according to the crystal structure, and the Te-modified T and native A interact similarly to the native T and A pair. Furthermore, STM imaging of the DNA duplex modified with electron-rich tellurium functionality revealed high topographic and current peaks whereas the equivalent native displayed faint signals, suggesting a viable method for directly imaging DNA without structural .. View More»
DOI:
10.14303/2250-9941.2022.42