Review Article
DNA mismatches repair activity in cells
Author(s): Angelina Martin*
Mismatch repair (MMR) is a highly conserved biological mechanism that is essential for genomic integrity. MMR
is most specific for base-base mismatches and insertion/deletion mispairs that occur during DNA replication and
recombination. MMR also slows homeologous recombination and has recently been linked to DNA damage
signaling in eukaryotic cells. MutS and MutL from Escherichia coli, as well as their eukaryotic homologs MutS and
MutL, are important participants in MMR-associated genome maintenance. Many additional protein components
involved in other DNA metabolic pathways, such as PCNA and RPA, are also required for MMR (Therese et al.,
2019). MMR mutations are linked to genome-wide instability, propensity to certain forms of cancer, including
hereditary non-polyposis colorectal cancer, resistance to some chemotherapeutic drugs, and meiotic and sterility
disorders in mammalian.. View More»
DOI:
10.14303/2250-9941.2023.72