Joachim Joseph Ajakaiye1, Asmau Asabe Muhammad2*, Melemi Richard Mazadu1, Yahya Shuaibu1, Bashir Adamu Kugu1, Bintu Mohammad1, Ramatu Lawan Bizi2 and Martina Sunday Benjamin2
Effect of intramuscular administration of Trypanocides on body temperature and serum chemistry in Wistar rats infected with Trypanosoma brucei brucei was investigated. 25 Wistar rats with average body weights of 200-240????±20 g were randomly divided into five groups. Group A was administered 0.5 mL of normal saline only, while group B was given 0.1 ????? 106 of T. brucei brucei only. Group C, D and E were inoculated the same dose of the parasite as in group B and they were intramuscularly administered with 3.5 mg/kg b.w. of Trypadim,1 mg/kg b.w. of Trypamidium and 1 mg/kg b.w. of Novidium respectively. Body temperature increased consistently in all groups except group A. However, there was a significant (p < 0.05) difference in all treated groups compared to group B on 28 day post-infection (DPI). All serum indicators increased significantly (p < 0.05) in group B when compared with all other groups. Values observed for creatinine in all treated groups was only significantly (p < 0.05) higher in group E when compared to group A. In conclusion, administered trypanocidal drugs possess antipyrexia activity and could off-set the negative effect of T.brucei.brucei on the measured serum chemistry in Wistar rats.
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