Ruiru Shi, Guolong Zhang, Xing Yuan, Huimin Shi, Zheng Li, Shu Qin, Huiyuan Bao, Xia Zhang, Wei Wang
To investigate antibody responses during treatment in tuberculosis patients from Henan Province, China. Forty-five smear-positive pulmonary tubercul osis patients, 43 smear-negative pulmonary tuberculosis patients , 43 extra pulmonary tubercul osis patients were enrolled to collect blood sample s at 0, 2, 4, 6, 8, 16, 24 weeks during tuberculosis treatment, totally 7 time points. Twenty-three heal thy controls were enrolled to collect blood samples onl y once. Sera were applied to analyze TB IgG antibody by ELISA kit made in China. The basic lev els of antibodies at 0 week in tuberculosis patient s were significantly higher than those in healthy peo ple. During treatment, the dynamic change of antibody was shown in different patterns. There was a significant decrease in antibody positivity with treatment for pulmonary tuberculosis patients. The present study signified that in resource-limited settings, antibody test may still be of some value in helping to diagnose tuberculosis and to monitor the treatment outcome.
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