To safeguard vulnerable populations, exposure-response data on the constituents of particulate air pollution are required. Particulate matter with a diameter of less than 2.5 millimetres (PM2.5) can produce reactive oxygen species which can lead to oxidative stress. Primary organics from combustion sources and secondary organics from volatile organic compounds that have been photo chemically oxidized are two examples. We looked at how primary and secondary organic particle components, size fractions, and the potential of particles to induce cellular production of reactive oxygen species differed in airway and systemic inflammatory responses.
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