GET THE APP

Evaluation of antimicrobial activity of designed peptides ag | 50014
International Research Journals
Reach Us +44 330 818 7254

International Research Journal of Pharmacy and Pharmacology

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Evaluation of antimicrobial activity of designed peptides against a Novel Class A β-lactamase in Klebsiella pneumoniae

Abstract

Karina Caetano Souza

Klebsiella pneumoniae is a Gram-negative bacterium that is one of the WHO’S priority ESKAPE pathogens which are responsible for a significant increase in mortality worldwide. It has also caused a massive economic burden due to presenting multidrug resistance in the causal pathogen at an alarming rate. The aim of this project is to reverse β -lactam drug resistance in Klebsiella pneumoniae by binding designed peptides (designed in silico, produced and purified) to the active site pocket of a novel Class A β – lactamase. Antibiotic sensitivity assessment of the cells harboring the β – lactamase in presence and absence of the peptides has shown some promising results. Alongside this, expression and purification of the novel β – lactamase is being approached for further structure-activity relationship studies.

Share this article