Udosen E. Orok, Egbung G. Eneji, Onofiok U. Luke, Robert A. Eyo, Ekam V.Sampson, Iwara A. Iwara and Odey M. Oko
Electrolytes in the body fluid have important effec ts on the overall balance and are essential for nor mal functionality of cell and body organs. This study e valuated the effect of ethanolic root and twig extr acts of Gongronema latifolium (GL) on kidney function of streptozotocin induced hyperg lycemic and normal Wistar rats. A total of sixty (60) Wistar rats were divided into 10 groups of 6 rats each. Groups A an d B served as normal (NC) and diabetic control (DC) res pectively and received dimethysulphoxide(DMSO). Groups C, D, E, F, G,H,I,J served as non-diabetic t reated and diabetic treated receiving single dose(200mg/kg b.w) and double dose (400mg/kg b.w) o f ethanolic twig and root extracts of GL respectively for 14days. Thereafter, the animals w ere sacrificed and blood collected for analyses of serum glucose, Na + , K + , Cl - , urea and creatinine. Our finding revealed a signi ficant decrease (P<0.05) in serum glucose concentration for all the groups trea ted with both ethanolic extracts of GL compared to diabetic and normal control. The serum urea concent ration showed a significant increase (P<0.05) in the SSDT-twig and DDDT-root compared to the diabeti c and non-diabetic rats, while the DDNT-root showed a significant decrease (P<0.05) compared to the diabetic and non- diabetic rats. Whereas, a significant decrease (P<0.05) was observed in Cl - level in DDNT-twig and SDDT-root respectively compared to diabetic and normal control. The creati nine concentrations in all treated groups showed a significant decrease (p<0.05) compared to the diabe tic and non-diabetic Wistar rats. These results confirm the probable anti-hyperglycemic activity an d kidney function potentials of the plant.
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