O.A. Sodipo, F.I. Abdulrahman and U.K. Sandabe
Studies were conducted on the effect of the aqueous fruit extract of Solanum macrocarpum Linn. in chronic titron-induced hyperlipidaemic rats. The pl ant was Soxhlet-extracted with distilled water and the extract concentrated in vacuo with a yield of 15.34% w / w . The extract was stored in a specimen bottle in a desicator at room temperature until whe n required. The kidney function parameters; serum creatinine, urea and electrolytes (sodium, potassiu m, calcium, and phosphate) were determined. The results showed that with increase in extract dose, the changes in serum concentration of sodium, potassium and phosphate ions were significant (P>0. 05). For calcium ions however, the concentration increase was significant (P<0.05) at 48 and 72hrs. Creatinine decreased significantly (P<0.05) at 72hr s and urea decreased significantly at 48hrs and 72hrs when compared to the negative control. Then non- significant changes in sodium and potassium ions im ply that the acid-base balance of the physiological system was not affected. Decreased le vels of creatinine and urea observed in this study probably implies the kidney is not damaged.
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