International Research Journal of Pharmacy and Pharmacology

Antibiotics 2020: Antibiotic sensitivity to Methicillin and Methicillin plus macrolide-Lincosamide-Streptogramins Resistant Staphylococcus Aureous-Hamzullah khan-Nowshera medical college

Abstract

Hamzullah khan

Abstract:

Objectives: Culture and Sensitivity pattern of Methicillin and Methicillin Plus Resistant Staphylococcus aureous (MRSA &MLS-B type MRSA) isolates (sputum and pus samples) in a tertiary care hospital of Nowshera.

Methods:

This cross sectional study was performed in the pathology laboratory of Qazi Hussain Ahmed Medical Complex Nowshera from 1^st May 2018 to 30^th Oct 2019. A total of 235 isolates were studies and 86 samples showed MRSA. Out of 86 MRSA, 19 were also resistant to Macrolide-lincosamide-streptogramin-B antibiotics (MLS-B). Relevant information were recorded on a predesigned proforma prepared as per CLSI Recommendation for data collection

Results:

Out of 235 patients, 86 MRSA  Positive isolates (36.59%) were selected for antibiotic susceptibility. Out of total, 52(60.5%) were females and 34(39.5%) were males. The mean age with standard deviation was 28.48+6.85. The age range was from 20 years to 55 years of age. Mode of age was 25years. The sensitivity pattern to MRSA was; Vancomycin 100%, Lanezolid 100%,Rifampicin 86.04%, Clindamycin, 73.25%, Fusidic acid 60.46% , Erythromycine 44.18%.,Doxycyclin 32.55%, levofloxacin 16.27%, Gentamycin13.95% and ciprofloxacin 11.62%. 27% cases with MRSA were also resistant to (MLS-B) antibiotics and were labeled as MPRSA (Methicillin plus resistant staph.aureus) present study.

It is further to exhibit that MRSA are prevalent in younger age (20-30 years) 61(68%) as compared to the older age mean youth under threat of MRSA.

Using logistic regression analysis it was noted that the probability of MRSA in female gender was 1.5 times more than male gender with a significant p-value (P-value=0.04, OR=1.54).

The sensitivity to Vancomycine & Lanezolid was 100 in MRSA and MLS-MRSA isolates.  

Conclusion: sensitivity of Vancomycin & Lanezolid was 100% in MRSA and should be kept reserved for MRSA cases to avoid misuse of antibiotics and to reduce resistance to these precious antibiotics. Methicillin resistant infections are now a challenge to the clinician and at the same time are extremely expensive to be afforded by a common person. MRSA is a public health threat that needs accumulative response through advocacy, communication and social mobilization.

Keyword: Antibiotic resistance, MRSA, Misuse of antibiotics.

Share this article