Akbar Nikkhah
The average human age is currently 75 years, which could increase up to 85 in the coming decades. It is not clearly known if and how these additional years will be adequately satisfying and healthful. The objective was to delineate most verified insights into aging physiology in humans in serving the public awareness and public education policy-making programs. Data suggest gains in the number of healthy years but also compromised physical, mental, and social functions. Decreased oxidative capacity of aged skeletal muscle is due to impaired mitochondrial function and lowered electron transport chain complex activities. Aging coincides with reduced endocrinological functions. Diet restrictions may elongate lifespan while retarding the occurrence of age-related pathologic alterations. Immune function in the elderly may be restored by practical interventions such as vaccination. Alzheimer’s disease may in part stem from poor nutritional habits at younger ages, especially with the intake of antioxidantspoor foods. Insights into mental disorders of aging are highly inadequate, thus needing novel innovative hypotheses and future experiments
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